LigSearch: a knowledge-based web server to identify likely ligands for a protein target

نویسندگان

  • Tjaart A. P. de Beer
  • Roman A. Laskowski
  • Mark-Eugene Duban
  • A. W. Edith Chan
  • Wayne F. Anderson
  • Janet M. Thornton
چکیده

Identifying which ligands might bind to a protein before crystallization trials could provide a significant saving in time and resources. LigSearch, a web server aimed at predicting ligands that might bind to and stabilize a given protein, has been developed. Using a protein sequence and/or structure, the system searches against a variety of databases, combining available knowledge, and provides a clustered and ranked output of possible ligands. LigSearch can be accessed at http://www.ebi.ac.uk/thornton-srv/databases/LigSearch.

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عنوان ژورنال:

دوره 69  شماره 

صفحات  -

تاریخ انتشار 2013